With the 100-400L II, I recently shot the moon and Jupiter. With IS on at 400mm, handheld shots I took at 1/320 second looked good enough to post one of them, as I did in the moon section. I cropped it and posted a 100% pixel peep. I didn’t add any extra sharpening, and just did a bit of highlight recovery in ACR. My camera won‘t shoot at 1/160,000 second anyway.